Method for the preparation of sevoflurane

Details Method for the preparation of sevoflurane Method for the preparation of sevoflurane

1997-08-18

1999-10-19

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07L 4100

Patent

active

059691930

ABSTRACT:
A method for the preparation of sevoflurane which comprises (a) providing a liquid mixture of (CF.sub.3).sub.2 CHOCH.sub.2 Cl, hydrogen fluoride, and an amine and (b) reacting the mixture, to form (CF.sub.3).sub.2 CHOCH.sub.2 F.

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Yoneda "The Combination of Hydrogen Fluoride with Organic Bases as Fluorination Agents" Tetrahedron, No. 294, vol. 47, No. 29, pp. 5329-5365, 1991.

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