Method for the preparation of S-(+)-ethodolic acid and saline de

Details Method for the preparation of S-(+)-ethodolic acid and saline de Method for the preparation of S-(+)-ethodolic acid and saline de

1994-06-29

1996-11-26

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491052

Patent

active

055787347

ABSTRACT:
Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of a mixture of alpha-(+)-phenethylamine enantiomers in an organic solvent. The resulting precipitate containing the salt of optically active phenethylamine and the S-(+)-enantiomer of the ethodolic acid is separated followed by isolation of the optically enantiomer. Salification of the acid with organic and inorganic bases, selected from basis amino acids, morpholine, aminopyridine and benzylalkyltrimethylammonium derivatives provides new therapeutically effective derivatives.

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Jacques, J. et al., Enantiomers, Racemates and Resolutions, John Wiley & Sons, New York, 1981, pp. 253-259.

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