Method for the preparation of pyrido benzoxazine derivatives

Details Method for the preparation of pyrido benzoxazine derivatives Method for the preparation of pyrido benzoxazine derivatives

1995-05-26

1999-09-14

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D49806

Patent

active

059524944

ABSTRACT:
There is disclosed a method for the preparation of pyrido benzoxazine derivative having the following formula I, that is improved in both production coat and yield.
The method comprises reacting a compound of the following general formula II with tetraalkyl ammonium fluoride or with a mixture of tetraalkyl ammonium halide and metal fluoride in an organic solvent at a reaction temperature of about 30 to about 100.degree. C. for 1 to 3 hours under stirring; and reacting the resulting solution with a metal hydroxide or a metal carboxylate dissolved in water or in a mixture of water and alcohol, for 1 to 3 hours under heat. ##STR1## wherein X is a fluorine or chlorine atom and X.sub.1 and X.sub.2 each is a halogen atom or a nitro group, R is an alkyl group containing 1 to 4 carbon atoms and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is an alkyd group or allyl group containing 1 to 8 carbon atoms.

REFERENCES:
patent: 5516926 (1996-05-01), Kim et al.
patent: 5516927 (1996-05-01), Kim et al.
patent: 5539110 (1996-07-01), Kim et al.
Bouzard, Chemical Abstract 110:57479 (1988).
Bouzard, Tetrahedron Letters, 29(16), pp. 1931-1934 (1988). Ofloxacin", Chem. Pharm. Bull 34 (10):4098-4102.

Affiliated with

Also associated with

Rating

Method for the preparation of pyrido benzoxazine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the preparation of pyrido benzoxazine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of pyrido benzoxazine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1511036