Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2001-05-11
2009-06-23
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S450000, C424S400000, C424S489000
Reexamination Certificate
active
07550157
ABSTRACT:
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium. The present invention also provides an efficient method to effectively incorporate a hydrophobic drug into a polymeric micelle in a polyethylene glycol separating medium.
REFERENCES:
patent: 5449513 (1995-09-01), Yokoyama et al.
patent: 5510103 (1996-04-01), Yokoyama et al.
patent: 5663168 (1997-09-01), Rosel et al.
patent: 5683723 (1997-11-01), Spenlehauer et al.
patent: 5702717 (1997-12-01), Cha et al.
patent: 5877205 (1999-03-01), Andersson
patent: 5922754 (1999-07-01), Burchett
patent: 0645145 (1997-12-01), None
Hawley's Condensed Chemical Dictonary, 14 ed. 2002 “Solvent” and “Organic Chemistry” disclosures. Dowloaded from the World Wide Web on Jul. 11, 2006.
Materials Safety Data Sheet for Polyethylene Glycol 400 Mar. 6, 2004.
Aliabadi et al, “Micelles of methoxy poly(ethylene oxide)-b-poly(eta-caprolactone) as vehicles for the solubilization ond controlled delivery of cyclosporine A” Journal of Controlled Release 104(2005) 301-311.
Szebeni et al “Complement activation by cremophor EL as a possible contributer to hypersensitivity to paclitaxel: an in vitro study” Journal of the National Cancer Institute vol. 90, 4, Feb. 18, 1998.
Kessel, D. “Properties of Cremophor EL Micelles Probed by Fluorescence” Photochemistry and Photobiology, vol. 56 No. 4, pp. 447-451, 1992.
Montazeri et al., Micelles of methoxy poly(ethylene oxide)-b-poly(e-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A. J. Controlled Release 104 (2005) 301-311.
K. Kataoka, Design of nanoscopic vehicles for drug targeting based on micellization of amphiphilic block copolymers, J. Macromol. Sci.-Pure Appl. Chem A31 (1994) 1759-1769.
H. Maeda, The tumor blood vessel as an ideal target for macromolecular anticancer agents, J. Control. Rel. 19(1992) 315-324.
Marie-Christine Jones, Jean-Christophe Leroux, Polymeric micelles—a new generation of colloidal drug carriers, European Journal of Pharmaceuticals and Biopharmaceutics 48 (1999) 101-111.
Xichen Zhang, John K. Jackon, Helen M. Burt, Development of amphiphilic diblock copolymers as micellar carriers of taxol, International Journal of Pharmaceutics 132 (1996) 195-206.
G .Kwon, et al., Block copolymer micelles for drug delivery: loading and release of doxorubicin, J. Contr. Rel. 48 (1997) 195-201.
G. Kwon, et al., Physical entrapment of Adriamycin in AB block copolymer micelles, Pharm. Res. 12 (1995) 92-195.
So Yeon Kim, et al, Methoxy poly(ethylene glycol) and ε-caprolactone amphiphilic block copolymric micell containing indomethacin. II. Micelle formation and drug release behaviours.
Marie-Christine Jones, Jean-Christophe Leroux, Polymeric micelles—a new generation of colloidal drug carriers, European Journal of Pharmaceuticals and Biopharmaceutics 48 (1999) 101-111.
Xichen Zhang, John K. Jackon, Helen M. Burt, Development of amphiphilic diblock copolymers as micellar carriers of taxol, International Journal of Pharmaceutics 132 (1996) 195-206.
G .Kwon, et al., Block copolymer micelles for drug delivery: loading and release of doxorubicin, J. Contr. Rel. 48 (1997).
G. Kwon, et al., Physical entrapment of Adriamycin in AB block copolymer micelles, Pharm. Res. 12 (1995) 92-195.
So Yeon Kim, et al, Methoxy poly(ethylene glycol) and ε-caprolactone amphiphilic block copolymric micell containing indomethacin. II. Micelle formation and drug release behaviours.
Marie-Christine Jones, Jean-Christophe Leroux, Polymeric micelles - a new generation of colloidal drug carriers, European Journal of Pharmaceuticals and Biopharmaceutics 48 (1999) 101-111.
Xichen Zhang, John K. Jackon, Helen M. Burt, Development of amphiphilic diblock copolymers as micellar carriers of taxol, International Journal of Pharmaceutics 132 (1996) 195-206.
Seo Min-Hyo
Yi Yil-Woong
Yu Jae-Won
Hartley Michael G.
Samyang Corporation
Silverman Eric E
Thorpe North & Western LLP
LandOfFree
Method for the preparation of polymeric micelle via phase... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the preparation of polymeric micelle via phase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of polymeric micelle via phase... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4070363