Method for the preparation of phenyl pyruvic acid

Details Method for the preparation of phenyl pyruvic acid Method for the preparation of phenyl pyruvic acid

1986-02-20

1987-08-25

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5110

Patent

active

046894314

ABSTRACT:
The invention provides an improvement in the method for the preparation of phenyl pyruvic acid by the reaction of benzyl chloride and carbon monoxide in a liquid reaction medium in the presence of a cobalt carbonyl as the catalyst. In the inventive method, the reaction is performed in the presence of calcium hydroxide and the reaction medium is a binary system composed of water and an organic solvent capable of dissolving the catalyst and not freely miscible with water. The reaction can proceed even under normal pressure and the desired product can be readily recovered in the form of precipitates of the calcium salt while the catalyst dissolved in the organic phase after completion of the reaction can be recycled and re-used as such in the next run so that the costs for the catalyst regeneration in the prior art can be entirely saved.

REFERENCES:
patent: 3116306 (1963-12-01), Heck
patent: 3928429 (1975-12-01), El-Chahawi
patent: 4128578 (1978-12-01), Cassar
patent: 4152352 (1979-05-01), Perron
patent: 4351952 (1982-09-01), Foa
patent: 4447644 (1984-05-01), El-Chahawi
patent: 4492798 (1985-01-01), Lee
patent: 4576809 (1986-03-01), Gauthier-Lafaye
"Lange's Handbook of Chemistry," 12th Ed., pp. 10-60 to 10-62, (1979).

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