Method for the preparation of pearls and pearls obtained contain

Details Method for the preparation of pearls and pearls obtained contain Method for the preparation of pearls and pearls obtained contain

1996-12-03

2000-06-13

Wu, David W.

Plastic and nonmetallic article shaping or treating: processes

Formation of solid particulate material directly from molten...

By extrusion spraying or gravity fall through orifice

264 9, 264 13, 427 214, B29B 900

Patent

active

060745800

ABSTRACT:
Pearls of an active principle exhibiting an indefinite crystallization point, wherein said pearls exhibit a prolonged, immediate or combination release profiles, are made by melting the active principle and a crystallization excipient to create a molten mixture; introducing the mixture into feed receptacles of a prilling tower; passing the mixture through a nozzle which is vibrated to form pearls; and allowing the pearls to fall in the tower countercurrentwise to cold air, where the tower is provided with a fluidized bed proximate the bottom of the tower and the temperature conditions of the said fluidized bed are maintained depending on the release profile desired.

REFERENCES:
patent: 5188838 (1993-02-01), Deleuil et al.

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