Method for the preparation of optically active 3-hydroxypyrrolid

Details Method for the preparation of optically active 3-hydroxypyrrolid Method for the preparation of optically active 3-hydroxypyrrolid

1991-09-24

1993-02-16

Elmore, Carolyn

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435121, 435135, C12P 4100

Patent

active

051870940

ABSTRACT:
A method for the preparation of optically active 3-hydroxypyrrolidine derivatives is disclosed, which comprises the steps of: hydrolyzing a mixture of (R)- and (S)-N-benzyl-3-acyloxypyrrolidine by the use of microorganisms or enzymes with stereospecific esterase activity; and separating optically active N-benzyl-3-hydroxypyrrolidine and optically active N-benzyl-3-acyloxypyrrolidine from the hydrolysate obtained in the foregoing step.

REFERENCES:
patent: 4916074 (1990-04-01), Yoshida et al.
"Chiral Synthesis via Organoboranes. 6. Hydroboration. 74. Asymmetric Hydroboration of Representative Heterocyclic Olefins with Diisopinocampheylborane. Synthesis of Heterocyclic Boronates and Heterocyclic Alcohols of Very High Enantiomeric Purity", Brown et al., J. Am. Chem. Soc. 1986, vol. 108, No. 8, pp. 2049-2054.
"Synthesis of 3S-Pyrrolidinol from L-Glutamic Acid", Harris et al., Synthetic Communications, vol. 16, No. 14, (1986), pp. 1815-1822.

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