Method for the preparation of optically active...

Details Method for the preparation of optically active... Method for the preparation of optically active...

2007-11-01

2011-10-25

Gonzalez, Porfirio Nazario (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfur containing

C568S814000, C502S155000

Reexamination Certificate

active

08044245

ABSTRACT:
Optically active 2-sulfonyloxy-1-phenylethanol derivative of formula (II) can be prepared easily and selectively by the method of the present invention using an asymmetric reduction of an α-sulfonyloxy acetophenone compound with a rhodium catalyst having petamethylcyclopentadienyl group and a hydrogen donor, and the compound of formula (II) obtained in the inventive method exhibits a higher e.e. (enantiomer excess) value than that of the products in the conventional methods.

REFERENCES:
Peach, P., et al., “Asymmetric transfer hydrogenation of α,β-unsaturated, α-tosyloxy and α-substituted ketones,” Tetrahedron, 62, 2006, 1864-1876.
Cross, D.J., et al., “Rhodium versus ruthenium: contrasting behaviour in the asymmetric transfer hydrogenation of α-substituted acetophenones,” Tetrahedron: Asymmetry 12 (2001) 1801-1806.
Cho, B.T., et al., “Convenient synthesis of optically active 1,2-diol monosulfonates and terminal epoxides via oxazaborolidine-catalyzed asymmetric borane reduction of α-sulfonyloxy ketones,” J. Chem. Soc., Perkin Trans. 1, 2001, 1204-1211.
Kim, D.J., et al., “A New Approach to the Synthesis of Optically Active Norephedrine, Norpseudoephedrine and Cathinone via Double Asymmetric Induction,” Bull. Korean Chem. Soc., 24:11, 2003. pp. 1641-1648.

Affiliated with

Also associated with

Rating

Method for the preparation of optically active... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the preparation of optically active..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of optically active... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4280988