Method for the preparation of N-glycolyl neuraminic acid from Cu

Details Method for the preparation of N-glycolyl neuraminic acid from Cu Method for the preparation of N-glycolyl neuraminic acid from Cu

2000-03-13

2000-11-07

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

424520, 424572, 435137, C12P 740, C12P 758, A61K 3512

Patent

active

061435333

ABSTRACT:
Disclosed is an efficient and economical method for the preparation of N-glycolyl neuraminic acid in a high purity from an inexpensive abundant source material. The method comprises dispersing body tissues of an echinodermatous marine animal Cucumaria echinata in an aqueous medium, preferably, using a dry powder of the tissues prepared in advance, in which the tissues are proteolytically decomposed to isolate N-glycolyl neuraminic acid in the form of an aqueous solution containing polypeptides as a by-product, followed by separation of N-glycolyl neuraminic acid from the aqueous solution by removing the polypeptides and purification of the compound in a process utilizing an ion-exchange treatments.

REFERENCES:
patent: 5985330 (1999-11-01), Collin

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