Method for the preparation of mycophenolate mofetil by...

Details Method for the preparation of mycophenolate mofetil by... Method for the preparation of mycophenolate mofetil by...

2005-07-25

2010-06-01

Lankford, L Blaine (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

C435S041000, C435S132000, C435S171000, C435S198000

Reexamination Certificate

active

07727751

ABSTRACT:
The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence ofCandida antarcticalipase, and in which the MPA esterification reaction is carried out in the presence ofCandida antarcticalipase using the corresponding alcohol as the solvent.

REFERENCES:
patent: 2004/0167130 (2004-08-01), Lee et al.
patent: WO03/042393 (2003-05-01), None
Santaniello Enzo, et al., “Lipase-catalyzed transesterification in organic solvents: applications to the preparation of enantiomerically pure compounds” Enzyme and Microbial Technology, vol. 15, No. 5, p. 367-382, 1993.
International Search Report and the Written Opinion for PCT/EP2005/053629 of Nov. 7, 2005.

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