Method for the preparation of monohydrate

Details Method for the preparation of monohydrate Method for the preparation of monohydrate

1989-02-23

1991-03-26

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50104

Patent

active

050030647

ABSTRACT:
Cefadroxil monohydrate is prepared by solubilizing 7-[D-(-)-.alpha.-benzyloxycarbonylamino-.alpha.-(p-hydroxyphenyl)acetamido ]-3-methyl-3-cephem-4-carboxylic acid by silylation or by salification in an organic solvent, subjecting the solubilized acid in the solvent to catalytic hydrogenation, separating the catalyst from the solution, and adding water to the solution at a pH of about 4 to precipitate cefadroxil monohydrate.

REFERENCES:
patent: 3489752 (1970-01-01), Crast
patent: 4504657 (1985-03-01), Buzard et al.

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