Method for the preparation of maytansinoid esters

Details Method for the preparation of maytansinoid esters Method for the preparation of maytansinoid esters

2007-11-27

2007-11-27

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

11334478

ABSTRACT:
Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.

REFERENCES:
patent: 6333410 (2001-12-01), Chari et al.
A. Kawai, et al., Chemical Modification of Ansamitocins. III Synthesis and Biological Effects of 3- Acyl Esters of Maytansinol, Chem. Pharm. Bull, 1984, pp. 3441-3451, vol. 32.

Affiliated with

Also associated with

Rating

Method for the preparation of maytansinoid esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the preparation of maytansinoid esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of maytansinoid esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3871189