Method for the preparation of in vitro-derived human neutrophil

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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424 931, 435326, 435366, 435372, A01N 6300, A61K 3514, C12N 500, C12N 502

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057006911

ABSTRACT:
A composition of human neutrophil precursor cells is disclosed wherein at least 16% of the cells are human myeloblasts and promyelocytes. The myeloblasts and promyelocytes are derived from human neutrophil progenitor cells that were obtained from peripheral blood, bone marrow or cord blood. The neutrophil precursor cells contain less than 5% colony forming units. Also disclosed are human neutrophil precursor cells made up of about 16% CD15+CD11b- cells and less than 5% colony forming units and methods of preparing these compositions.

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