Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07126015

ABSTRACT:
The present invention relates to a method for the preparation of hexahydro-furo[2,3-b]furan-3-ol as well as novel intermediates for use in said method. More in particular the invention relates to a stereoselective method for the preparation of hexahydro-furo[2,3-b]furan-3-ol, and to a method amenable to industrial scaling up.

REFERENCES:
patent: 94/26749 (1994-11-01), None
patent: WO 95/06030 (1995-03-01), None
patent: WO 99/67417 (1999-12-01), None
patent: WO 01/25240 (2001-04-01), None
Schreiber et al., Tetrahed. Letter, (1986), vol. 27(23), pp. 2575-2578.
Schreiber et al., Tetrahed. Letter, (1988), vol. 29(51), pp. 6689-6692.
Arun K. Ghosh et al., Nonpeptidal P2Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation, J. Med. Chem., 1996, 39, pp. 3278-3290.
M. Pezechk et al., A New Route to Perhydro- and Tetrahydro- Furo-2,3b Furans via Radical Cyclisation, Tetrahydron Letters, vol. 27, No. 32, pp. 3715-3718, 1986.
M. Uchiyama et al., Steroselective synthesis of optically active perhydrofuro[2,3-b]furan derivatives, Tetrahedron Letters 42 (2001) pp. 4653-4656.

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