Method for the preparation of granulates suited for the producti

Details Method for the preparation of granulates suited for the producti Method for the preparation of granulates suited for the producti

1987-03-02

1988-11-22

Silbaugh, Jan H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

264117, 264122, 264112, 424478, 424480, 424481, A61K 926

Patent

active

047865067

ABSTRACT:
A method for the preparation of tablets slowly releasing the active principle, characterized in that (I) during the granulation step a solution in organic solvents of a polymer insoluble in biological juices is sprayed on a mixture containing an active principle, slightly swelling polymers and usual excipients; (II) the granulated obtained in this way is added with a highly hydroswelling colloidal polymer; (III) a solution, in organic solvents, of an entero-soluble polymer, is sprayed on the granulate; (IV) the resulting granulate is submitted to compression; (V) the obtained tablets are hardened by washing with organic solvents; and (VI) they are then optionally coated.

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