Method for the preparation of fibrates

Details Method for the preparation of fibrates Method for the preparation of fibrates

1987-04-27

1988-04-19

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 62, 560 45, C07C 6976

Patent

active

047391014

ABSTRACT:
The present invention relates to a method for the preparation of fibrates of the formula I according to the mechanism: ##STR1## in which R.sub.1 represents especially a halogen atom (in particular F, Cl or Br, the preferred halogen atom being Cl) or an acetyl, (4-chlorophenyl)hydroxymethyl, 4-chlorobenzoyl or 2-(4-chlorobenzamido)ethyl group and R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group in which the hydrocarbon chain is linear or branched, the reaction V+VI being carried out without a solvent.

REFERENCES:
patent: 3759950 (1973-09-01), Grant
patent: 3795691 (1974-03-01), Douglas

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