Method for the preparation of derivatives of uracil

Details Method for the preparation of derivatives of uracil Method for the preparation of derivatives of uracil

1978-03-08

1979-06-26

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544314, C07D23954

Patent

active

041593782

ABSTRACT:
A novel and very elegant method is proposed for the preparation of N.sub.1 -(2-tetrahydrofuryl)-5-substituted or -unsubstituted uracil, especially, N.sub.1 -(2-tetrahydrofuryl)-5-fluorouracil, by the reaction of the corresponding 5-substituted uracil compound with 2,3-dihydrofuran. The reaction is performed in the presence of a chlorosilane compound, e.g. dimethyldichlorosilane, and a catalytic amount of an organic amine compound and can proceed very rapidly without disadvantageous side reactions to give the objective compound with high purity in a high yield.

REFERENCES:
patent: 3635946 (1972-01-01), Giller et al.
patent: 4039546 (1972-08-01), Giller et al.
patent: 4121037 (1978-10-01), Nakamura et al.

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