Method for the preparation of crystalline dexloxiglumide and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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Details

C562S449000, C562S450000

Reexamination Certificate

active

07662994

ABSTRACT:
The present invention describes a novel method for the purification of dexloxiglumide by crystallization from isopropyl ether which permits the production, in a reproducible manner, of a product with morphological and particle-size characteristics such as to favor its use in the preparation of oral pharmaceutical forms on an industrial scale.

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Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Martin Katschinski: “Loxiglumide. Rotta Research”, XP002306781, retrieved form STN Databse accession No. 2002: 580170 abstract & IDRUGS, 5(5), 469-474 CODEN: IDRUFN; ISSN: 1369-7056, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Gabro Vargas: “DexIoxiglumide. (Rotta Research Lab)”, XP002306782, retrieved form STN Databse accession No. 2002: 580010 abstract & Current Opinion in Investigational Drugs, 3(4), 621-626 Coden: COIDAZ; ISSN: 1472-4472, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; M. Fried, et al.: “The Role of Fat and Cholecystokinin in Functional dyspepsia”, XP002306783, retrieved form STN Databse accession No. 2002: 577063 abstract & GUT, 51(Suppl. 1), 154-157 CODEN: GUTTAK; ISSN: 0017-5749, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; S. Persiani, et al.: “Pharmacokinetics of DexIoxiglumide after Administration of single and repeat oral escalating doses in healthy young males”, XP002306784, retrieved form STN Databse accession No. 2002: 485631 abstract & International Journal of Clinical Pharmacology and Therapeutics, 40(5), 198-206 CODEN: ICTHEK; ISSN: 0946-1965, 2002.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; M. Maselli, et al.: “Effect of three nonpeptide Cholecystokinin antagonists on human isolated gallbladder”, XP002306785, retrieved form STN Databse accession No. 2002: 50662 abstract & Digestive Diseases and Sciences, 46(12), 1773-2778 CODEN: DDSCDJ; ISSN: 0163-2116, 2001.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Laura Revel, et al.: “DexIoxiglumide: CCK1 (CCKA) receptor antagonish treatment of irritable bowel syndrome”, XP002306939, retrieved form STN Databse accession No. 1999: 656782 abstract & Drugs of the Future, 24(7), 725-728 CODEN: DRFUD4; ISSN: 0377-8282, 1999.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; Gabor Varga, et al.: “Different form actions of CCK on pancreatic and gastric growth in the rat: effect of CCKA receptor blockade”:, XP002306940, retrieved fo STN Databse accession No. 1998: 370098 abstract & British Journal of Pharmacology, 124(3), 435-440 CODEN: BJPCBM; ISSN: 0007-1188, 1998.
Database CA ′Online! Chemical Abstracts Service, Columbus, Ohio, US; C. Scarpignato, et al.: “Effect of DexIoxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: Evaluation of their receptor selectively in vivo”, XP002306786, retrieved form STN Databse accession No. 1996 398396 abstract & Alimentary Pharmacology, 10(3), 411-419 CODEN: APTHEN; ISSN: 0629-2813, 1996.

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