Method for the preparation of calcium heparinate

Details Method for the preparation of calcium heparinate Method for the preparation of calcium heparinate

1980-08-11

1983-10-11

Spear, Jr., Frank A.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210651, B01D 1300

Patent

active

044091036

ABSTRACT:
A process for the preparation of the calcium salt of heparin containing an amount of sodium by weight not in excess of 0.1% and containing an amount of calcium by weight not less than 9.5% is described, which comprises subjecting a solution of sodium heparinate to dialysis, hyperfiltration (inverse osmosis) or ultrafiltration by means of a semi-permeable membrane and isolating the calcium heparinate with anticoagulant activity essentially equal to the anticoagulant activity of the sodium heparinate. For the ultrafiltration, a membrane may be used in the form of a planar sheet or a membrane in the form of a spiral or "needle" having a molecular nominal cut-off at 20,000 Dalton. For the hyperfiltration (inverse osmosis), a membrane may be used having a rejection of sodium ion between 0 and 75%. For the dialysis, a membrane may be used in the form of multiple sheets or a coiled tube or hollow fibers. A plurality of dialyzers in series or in parallel is used. The process may be carried out continuously or discontinuously.

REFERENCES:
patent: 3228877 (1966-01-01), Mahon
patent: 3817831 (1974-06-01), Mancilla et al.
Michaels, "New Separation Technique for the CPI", from Chem. Eng. Progress, vol. 64, No. 12, 12-1968, pp. 31-43, 210-651.
Porter et al., Membrane Ultrafiltration, from Chem. Tech., Jan. 1971, pp. 56-63.

Affiliated with

Also associated with

Rating

Method for the preparation of calcium heparinate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the preparation of calcium heparinate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the preparation of calcium heparinate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1274173