Method for the preparation of baccatin III and derivatives there

Details Method for the preparation of baccatin III and derivatives there Method for the preparation of baccatin III and derivatives there

1997-05-21

1999-02-23

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

058745955

ABSTRACT:
10-Deacetylbaccatin III is selectively acylated to baccatin III and derivatives thereof in high yield with anhydrides (e.g. acetic anhydride), catalysed by Lewis acids. Extremely effective catalysts in this reaction are compounds of the formula ML.sub.x wherein M is a rare earth metal and L is a anion, preferably a strong electron withdrawing counterion such as triflate.

REFERENCES:
patent: 5629433 (1997-05-01), Zheng et al.
K. Ishihara et al., "Scandium Trifluoromethanesulfonate as an Extremely Active Acylation Catalyst", J. Am. Chem. Soc., vol. 117, No. 15, pp. 4413-4414, 1995.
F. Gueritte-Voegelein et al., "Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives", Tetrahedron, vol. 42, No. 16, pp. 4451-4460, 1986.

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