Method for the preparation of arylalkanolamineacylates

Details Method for the preparation of arylalkanolamineacylates Method for the preparation of arylalkanolamineacylates

1992-10-02

1994-08-16

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564358, 564355, 564364, 564139, 564184, 564186, 564217, 564218, 564219, 564223, C07C20900

Patent

active

053388844

ABSTRACT:
Acylamides or amine acylate salts of arylalkanolamines are prepared by reacting an arylisonitrosoalkanone with hydrogen and a carboxylic acid, carboxylic acid anhydride or carboxylic acid ester or mixture thereof in the presence of a transition metal catalyst; optionally the product is converted to the corresponding arylalkanolamine hydrochloride salt by reaction of the acylamide or amine acylate salt of the arylalkanolamine with hydrogen chloride in a C.sub.1 -C.sub.3 alkyl alcohol.

REFERENCES:
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patent: 3028429 (1962-04-01), Wilbert et al.
patent: 3966813 (1976-06-01), Satzinger et al.
patent: 5220063 (1993-06-01), Tafesh et al.
Morrison and Boyd, Organic Chemistry, Sixth Edition.COPYRGT. 1992 Prentice Hall, Inc. p. 864.

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