Method for the preparation of antibody-fragment conjugates

Details Method for the preparation of antibody-fragment conjugates Method for the preparation of antibody-fragment conjugates

1988-02-03

1990-06-26

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435188, 435272, 436512, 436547, 436548, 935107, 530388, 530389, 424 9, C12P 2106, G01N 33563, C07K 1528, A61K 4900

Patent

active

049371835

ABSTRACT:
A novel method for preparing soluble antibody fragment compositions having superior characteristics for targeted delivery when administered in vivo are disclosed. The antibody fragment compositions are characterized by substantially the same immunospecificity as the unconjugated antibody and aqueous solubility such that they are suitable for in vivo administration. Therapeutic and diagnostic methods utilizing the antibody fragment compositions are also disclosed.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4671958 (1986-03-01), Rodwell et al.
patent: 4814433 (1989-03-01), Fredrickson
Parham, P., et al., J. Immunol. Methods, 53: 133-173 (1982).
Parham, P., J. Immunol., 131:2895-2902 (1983).
Goodman, J. W., "Immunoglobulins I: Structure and Function", in Basic and Clinical.
Immunology, Lange Medical Publications, Los Altos, Calif. (Stites et al., ed.) pp. 30-36 (1982).

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