Method for the preparation of an immune globulin solution suitab

Details Method for the preparation of an immune globulin solution suitab Method for the preparation of an immune globulin solution suitab

1980-09-22

1982-03-30

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

260112B, 424101, 424177, A61K 3900, A61K 39395

Patent

active

043224032

ABSTRACT:
An immune globulin solution suitable for intravenous use is produced by purifying a salt-containing solution of an immune globulin in a number of adsorptive purification steps using an aqueous, humid, amorphous, chemically pure silicic acid of sub-microscopically fine distribution as the adsorption agent. In each step, the adsorption agent is suspended in the solution, the suspension is incubated for 30 to 60 minutes at about 20.degree. C. while being stirred and the adsorption agent is removed. During at least the first purification step the pH of the suspension is at a value of about 6.8.+-.0.05 (20.degree. C.) and during a subsequent purification step the pH of the suspension is at a value of about 6.5.+-.0.05 (20.degree. C.).

REFERENCES:
patent: 3607857 (1971-07-01), Nelson
patent: 4136094 (1979-01-01), Condie

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