Method for the preparation of .alpha..sup.1 [[(1,1-dimethylethyl

Details Method for the preparation of .alpha..sup.1 [[(1,1-dimethylethyl Method for the preparation of .alpha..sup.1 [[(1,1-dimethylethyl

1990-04-20

1991-04-30

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C24902, C07C25124

Patent

active

050119931

ABSTRACT:
There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]- 2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.

REFERENCES:
patent: 3644353 (1972-02-01), Lunts et al.
patent: 4021485 (1977-05-01), Schromm et al.
patent: 4112583 (1977-03-01), Wetterlin et al.
patent: 4154761 (1979-05-01), Collins et al.
Collin, Journal of Medicinal Chemistry, 13, No. 4, 674 (1970).

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