Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-08-02
2011-08-02
Desai, Anand (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C514S001100, C514S013400, C514S013500, C514S015100
Reexamination Certificate
active
07989593
ABSTRACT:
A high temperature-stable and highly purified cross-linked (optionally ≧70% β-β linked) tetrameric hemoglobin with high efficiency of oxygen delivery suitable for use in mammals without causing renal injury and vasoconstriction is provided. The dimeric form of hemoglobin is degenerated and purification processes are performed on red blood cells from whole blood. Controlled hypotonic lysis in an instant cytolysis apparatus prevents lysis of white blood cells. Nucleic acids from white blood cells and phospholipids impurities are not detected. Blocking of reactive sulfhydryl groups by a sulfhydryl reagent is performed in an oxygenated environment. Flowthrough column chromatography removes different plasma protein impurities. N-acetyl cysteine is added to the cross-linked tetrameric hemoglobin to maintain a low level of met-hemoglobin. The stabilized hemoglobin is preserved in an infusion bag with aluminum overwrap to prevent formation of inactive met-hemoglobin from oxygen intrusion. The product finds use in tissue oxygenation and cancer treatment.
REFERENCES:
patent: 4529719 (1985-07-01), Tye
patent: 4543209 (1985-09-01), Tayot et al.
patent: 4598064 (1986-07-01), Walder
patent: 4600531 (1986-07-01), Walder
patent: 4831012 (1989-05-01), Estep
patent: 4987048 (1991-01-01), Shinozaki et al.
patent: 5084558 (1992-01-01), Rausch et al.
patent: 5189146 (1993-02-01), Hsia
patent: RE034271 (1993-06-01), Walder
patent: 5250665 (1993-10-01), Kluger et al.
patent: 5296465 (1994-03-01), Rausch et al.
patent: 5344393 (1994-09-01), Roth et al.
patent: 5439882 (1995-08-01), Feola et al.
patent: 5451205 (1995-09-01), Roth et al.
patent: 5591710 (1997-01-01), Hsia
patent: 5618919 (1997-04-01), Rausch et al.
patent: 5631219 (1997-05-01), Rosenthal et al.
patent: 5691453 (1997-11-01), Wertz et al.
patent: 5725839 (1998-03-01), Hsia
patent: 5741893 (1998-04-01), Hsia
patent: 5753616 (1998-05-01), Rausch et al.
patent: 5767089 (1998-06-01), Hsia
patent: 5789376 (1998-08-01), Hsia
patent: 5804561 (1998-09-01), Hsia
patent: 5807831 (1998-09-01), Hsia
patent: 5811005 (1998-09-01), Hsia
patent: 5814601 (1998-09-01), Winslow et al.
patent: 5817528 (1998-10-01), Bohm et al.
patent: 5817632 (1998-10-01), Hsia
patent: 5824781 (1998-10-01), Hsia
patent: 5840701 (1998-11-01), Hsia
patent: 5840851 (1998-11-01), Plomer et al.
patent: 5865784 (1999-02-01), Faithfull et al.
patent: 5895810 (1999-04-01), Light et al.
patent: 5905141 (1999-05-01), Rausch et al.
patent: 5955581 (1999-09-01), Rausch et al.
patent: 6007774 (1999-12-01), Faithfull et al.
patent: 6054427 (2000-04-01), Winslow
patent: 6127043 (2000-10-01), Lange
patent: 6160098 (2000-12-01), Kerwin
patent: 6242417 (2001-06-01), Gerber et al.
patent: 6270952 (2001-08-01), Cook et al.
patent: 6288027 (2001-09-01), Gawryl et al.
patent: 6323175 (2001-11-01), Hsia
patent: 6399357 (2002-06-01), Winge
patent: 6432918 (2002-08-01), Winslow
patent: 6486306 (2002-11-01), Winge
patent: 6506725 (2003-01-01), Rausch et al.
patent: RE038081 (2003-04-01), Faithfull et al.
patent: 6566504 (2003-05-01), Bhattacharya et al.
patent: 6599878 (2003-07-01), Rooney
patent: 6610832 (2003-08-01), Gawryl et al.
patent: 6709810 (2004-03-01), Cook et al.
patent: 6740139 (2004-05-01), Russell et al.
patent: 6747132 (2004-06-01), Privalle et al.
patent: 6844317 (2005-01-01), Winslow et al.
patent: 6894150 (2005-05-01), Tye
patent: 7038016 (2006-05-01), Talarico et al.
patent: 7101846 (2006-09-01), Winslow
patent: 7293985 (2007-11-01), Cook et al.
patent: 7411044 (2008-08-01), Avella et al.
patent: 7435795 (2008-10-01), McGinnis et al.
patent: 7494974 (2009-02-01), Tye
patent: 7501499 (2009-03-01), Acharya et al.
patent: 7504377 (2009-03-01), Tye
patent: 7553613 (2009-06-01), Gawryl et al.
patent: 7625862 (2009-12-01), Winslow et al.
patent: 7655392 (2010-02-01), Stassinopoulos
patent: 7759306 (2010-07-01), Simoni et al.
patent: 7795401 (2010-09-01), Huang et al.
patent: 7932356 (2011-04-01), Wong et al.
patent: 2007/0142626 (2007-06-01), Kluger et al.
Malavalli, J. of Protein Chemistry, vol. 19, No. 4, 2000, pp. 255-267.
Hu, Biochem. J. vol. 402, 2007, pp. 143-151.
Jones, J. of Biological Chemistry, vol. 271, No. 2, 1996, pp. 675-680.
Chatterjee, J. of Biological Chemistry, vol. 261, No. 21, 1986, pp. 9929-9937.
Ji, Proteins: Structure, Function, and Genetics, vol. 30, 1998, pp. 309-320.
Kavanaugh, Biochemistry, vol. 27, 1988, pp. 1804-1808.
Kwansa, Proteins: Structure, Function, and Genetics, vol. 39, 2000, pp. 166-169.
Manning, Proc. Nat'l. Acad. Sci. USA, vol. 88, 1991, pp. 3329-3333.
Snyder, Proc. Nat'l. Acad. Sci, USA, vol. 84, 1987, pp. 7280-7284.
Napolitano LM., “Hemoglobin-based oxygen carriers: first, second or third generation? Human or bovine? Where are we now?”, Crit Care Clin. 25, 279-301 (2009).
Jiin-Yu Chen et al., “A review of blood substitutes: examining the history, clinical trial results, and ethics of hemoglobin-based oxygen carriers”, Clinics 64(8), 803-813 (2009).
Lamy ML et al., “Randomized Trial of Diaspirin Cross-linked Hemoglobin Solution as an Alternative to Blood Transfusion after Cardiac Surgery”, Anesthesiology 92(3), 646-656 (2000).
Lois R. Manning et al., “Subunit dissociations in natural and recombinant hemoglobins”, Protein Science 5(4), 775-781 (1996).
Ronald Kluger et al., “Protein-protein coupling and its application to functional red cell substitutes”, Chem Commun (Camb). 46(8), 1194-1202 (2010).
Ronald Kluger, “Red cell substitutes from hemoglobin—do we start all over again?”, Current Opinion in Chemical Biology 14(4), 538-543 (2010).
Kenji Sampel et al., “Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion”, Am J Physiol Heart Circ Physiol 289(3), H1191-H1201 (2005).
Tao Hu et al., “Preparation and characterization of dimeric bovine hemoglobin tetramers”, Journal of Protein Chemistry 22(5), 411-416(2003).
Tao Hu et al., “PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin”, Biochemistry 48(3), 608-616 (2009).
Kim D Vandegriff et al., “Hemospan: design principles for a new class of oxygen therapeutic”, Artificial organs 33(2), 133-138 (2009).
Thoralf Kerner et al., “DCL-Hb for trauma patients with severe hemorrhagic shock: the European “On-Scene” multicenter study”, Intensive Care Medicine 29(3), 378-385 (2003).
Chad R, Haney et al., “Purification and chemical modifications of hemoglobin in developing hemoglobin based oxygen carriers”, Advanced Drug Delivery Reviews 40(3), 153-169 (2000).
Donat R. Spahn et al., “Artificial O2 carriers : Status in 2005”, Current pharmaceutical design 11(31), 4099-4114 (2005).
Andre F. Palmer et al., “Tangential flow filtration of hemoglobin”, Biotechnol Prog. 25(1), 189-199 (2009).
David C. Irwin et al., “Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat”, Am J Physiol Heart Circ Physiol 295(3), H1090-H1099 (2008).
Guoyong Sun et al, “Preparation of Ultrapure Bovine and Human Hemoglobin by Anion Exchange Chromatography”, J Chromatogr B Analyt Technol Biomed Life Sci. 867(1), 1-7 (2008).
Ylping Jia et al., “Effects of cross-linking and zero-link polymerization on oxygen transport and redox chemistry of bovine hemoglobin”, Biochimica et Biophysica Acta 1794(8), 1234-1242 (2009).
Cai Jin et al., “Chemically Modified Porcine Hemoglobins and Their Biological Properties”, Protein and Peptide Letters, vol. 11, No. 4, 353-360 (2004).
Kwok Sui Yi
Wong Bing Lou
Burke Margaret
Desai Anand
Ella Cheong (Hong Kong) Ltd.
Yip Sam
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