Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-

Details Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4- Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-

1993-02-19

1994-05-10

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549401, C07D31158

Patent

active

053109520

ABSTRACT:
A novel process for the preparation of aminochromans of the general formula: ##STR1## wherein R is a C.sub.1 -C.sub.4 alkyl group. In the process, a nitrochromanone of the general formula: ##STR2## is hydrogenated with hydrogen in the presence of a hydrogenation catalyst. The resultant aminochromanone (III) is reduced using zirconium oxide/isopropanol to the aminochromene (IV). The latter is finally hydrogenated with hydrogen in the presence of a hydrogenation catalyst to give the final product. The aminochromans are useful intermediates for the preparation of hypolipidaemic pharmaceuticals.

REFERENCES:
patent: 5030601 (1991-07-01), Michel et al.
J. Med. Chem., 32, (1989), pp. 421 to 428.
Shibagaki et al., Bull. Chem., Soc., Japan, 61, (1988), pp. 3283 to 3288.

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