Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-12-19
2006-12-19
Tucker, Zachary C. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
active
07151178
ABSTRACT:
Methods for the preparation of pharmaceutically acceptable salts of 5-methylpyrazine-carboxylic acid-4-oxide by using the oxidizing agent OXONE® for the N-oxidation of C1-4methylpyrazinecarboxylic acid esters. The pharmaceutically acceptable salts are then formed by the saponification of the esters followed by alcohol precipitation.
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Mckay et al, “Oxidation Methods for Aromatic Diazines: Substituted Pyrazine-N-oxides, Pyrazine-N,N′dioxides, and 2,2′:6′,2″-terpyridine-1, 1″-dioxide” Heterocyclic Communications, vol. 7(4), pp. 307-312 (2001). As Abstracted by CAS Online (“CAPLUS”).
Ambrogi et al, “Antilipolytic Activity of a Series of Pyrazine-N-Oxides” European Journal of Medicinal Chemistry, vol. 15(2), pp. 157-163 (1980).
McKay et al, “Oxidation Methods for Aromatic Diazines: Substituted Pyrazine-N-Oxides, Pyrazine -N,N-Dioxides, and 2,2′:6′,2″-Terpyridine-1,1″-Dioxide” Heterocyclic Communications, vol. 7(4), pp. 307-312 (2001).
DuPont Oxone® monopersulfate compound—Technical Information.
Caudill Jonathan
Cooney Mark
Nigam Satish C.
Balogh Imre
Davis William J.
ISP Investments Inc.
Tucker Zachary C.
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