Method for the preparation of 4-phenyl-1,3-benzodiazepines and p

Details Method for the preparation of 4-phenyl-1,3-benzodiazepines and p Method for the preparation of 4-phenyl-1,3-benzodiazepines and p

1985-07-23

1987-11-24

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C10344

Patent

active

047090936

ABSTRACT:
A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can then be quenched with N-benzylidenemethylamine to form compound II. Hydrolysis of compound(II)yields the free base ##STR4## or its salt, which can be cyclized to form 4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine or its physiologically acceptable salts, which are useful as pharmacological agents.

REFERENCES:
patent: 3510560 (1970-05-01), Saunders
patent: 4309424 (1982-01-01), Martin et al.

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