Method for the preparation of 2-fluoro-4-monobromomethylbiphenyl

Details Method for the preparation of 2-fluoro-4-monobromomethylbiphenyl Method for the preparation of 2-fluoro-4-monobromomethylbiphenyl

1979-06-28

1981-07-14

Torrence, Dolph H.

Chemistry: electrical and wave energy

Processes and products

Processes of treating materials by wave energy

260465G, 260465D, 562492, 570129, B07J 110, C07C 2518

Patent

active

042785162

ABSTRACT:
2-(2-Fluoro-4-biphenylyl)propionic acid is prepared from 2-amino-4-methyl-biphenyl via a series of novel intermediates. In particular 2-amino-4-methylbiphenyl is converted to 2-fluoro-4-methylbiphenyl, the methyl group is brominated to form 2-fluoro-4-monobromomethylbiphenyl which is transformed into 2-(2-fluoro-4-biphenylyl)acetonitrile. This acetonitrile is then converted to fluorbiprofen via the corresponding propionitrile or it may be converted into fluorbiprofen via the intermediate ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate.

REFERENCES:
patent: 3755427 (1973-08-01), Adams et al.
patent: 3959364 (1976-05-01), Armitage et al.
Engel et al., Chemical Abstracts, vol. 83, 96748n (1975).

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