Method for the manufacture of therapeutic compounds and...

Details Method for the manufacture of therapeutic compounds and... Method for the manufacture of therapeutic compounds and...

2007-03-14

2011-10-04

Young, Shawquia (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrite esters or chalcogen analogues thereof

Reexamination Certificate

active

08030511

ABSTRACT:
Organic nitrites can be produced from a compound which is a mono/polyhydric alcohol or an aldehyde- or ketone-derivate thereof after de-aeration of the same, using NO gas, and stored in an environment saturated with gaseous NO. Organic nitrites produced according to the invention exhibit less impurities and improved storage stability compared to conventionally produced nitrites. The organic nitrites of the invention can easily be formulated into pharmaceutical compositions and have utility for the treatment of various conditions.

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Grossi et al. (Oct. 29, 1999). “A new synthesis of alkyl nitrites: the reaction of alkyl alcohols with nitric oxide in organic solvents,”J Org Chem64(22):8076-9.

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