Method for the manufacture of the derivatives of propionic acid

Details Method for the manufacture of the derivatives of propionic acid Method for the manufacture of the derivatives of propionic acid

1993-05-10

1994-03-22

Evans, Joseph E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549541, 549549, C07D30132, C07D30312, C07D30322

Patent

active

052966186

ABSTRACT:
A method is provided for supplying the desired optical isomer of a derivative of epoxypropionic acid from a racemix mixture. A representative derivative of epoxypropionic acid is an ester of (p-methoxyphenyl)epoxypropionic acid. The racemic mixture initially is dissolved in carbon dioxide and the resulting solution is passed through a chromatographic column. The desired isomer is subsequently separated from the resulting eluant. In a preferred embodiment the chromatographic column is packed with microcrystallized cellulosetriacetate, cellulose-tris-(3,5-dimethylphenylcarbamate), or cellulose-tris-(p-methylphenylcarbamate).

REFERENCES:
patent: 4252728 (1981-02-01), Delay
patent: 4430339 (1984-02-01), Eistetter et al.
"Retention and Selectivity in Carbon Dioxide Supercritical Fluid Chromatography with Various Stationary Phases", P. Mourier, et al., Journal of Chromatography, 353 (1986) 61-75, Elsevier Science Publisher B.V., Amsterdam.
"Carbon Dioxide Supercritical Fluid Chromatography on a Chiral Diamide Stationary Phase for the Resolution of D- and L-Amino Acid Derivatives", Shoji Hara et al., Journal of Chromatography, 371 (1986) 153-158, Elsevier Science Publisher B.V., Amsterdam.

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