Method for the manufacture of the cis-2-hydroxy-2-phenyl-r-1-cyc

Details Method for the manufacture of the cis-2-hydroxy-2-phenyl-r-1-cyc Method for the manufacture of the cis-2-hydroxy-2-phenyl-r-1-cyc

1976-11-08

1978-11-14

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

2603403, 568807, C07C 6514

Patent

active

041255585

ABSTRACT:
A known effective choleretic, cis-2-hydroxy-2-phenyl-r-1-cyclohexane carboxylic acid is obtained with a novel method wherein 1-phenylcyclohexene is reacted with formaldehyde in formic acid or mixture of formic acid with other solvents. The reaction mixture is hydrolyzed (alkaline hydrolysis) to provide a substituted cyclohexanol concurrently with a substituted dioxan. The substituted diol is separated from the substituted dioxan and finally oxidized to obtain the expected acid.

REFERENCES:
zimmerman, H. E. et al., J.A.C.S., 76, #9, 2285-2290, 1954.

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