Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1992-10-20
1994-03-01
Johnston, Jill A.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
422 58, 427 2, 427358, 4273899, 427420, 4274342, G01N 3122, B05D 126, B05D 300
Patent
active
052905152
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a method for the manufacture of a self-supporting test field material of very small layer thickness and to such a test field material.
For the quantitative and/or qualitative analytical determination of constituents of body fluids, especially blood and urine, so-called carrier-bound tests are increasingly being used. In these, a reagent system is embedded in at least one single-layer or multi-layer test field of a test carrier (in the English-language literature frequently also called "solid reagent analysis element"), said test field being placed in contact with the sample. The reaction of sample and reagent leads to an optically or otherwise detectable change, which can be evaluated visually or by means of an instrument (usually by reflection photometry).
The layer thickness of the test field materials used is very important for the quality of the analysis. In general, a layer thickness as thin as possible is aimed for. An intense colour formation, extremely important for the accuracy of the analysis, can thereby be achieved with a small quantity of reagents. Layer thinness furthermore reduces the quantity of sample fluid required. This is particularly important when, with the use of modern analytical methods, a plurality of analyses are to be performed on a single drop of blood (obtained by pricking the finger).
For this reason thin reagent films, in some cases less than 0.1 mm thick, are often used. They are manufactured in a layer-forming method by applying a film-forming mass (reagent film mass) to a carrier layer (usually a transparent plastic film). The reagent film mass is based on a dispersion or solution of a polymeric film former and contains the reagents required in the respective test layer.
In general, such reagent films are produced in the test carrier together with the carrier material (for example set in a frame or bonded on to a strip-type base layer). Removal of the film layer from the carrier film on which it was formed has also been described. However, with the use of thin films this is not feasible in practice.
There is therefore a need for a test material of extreme thinness (less than 0.1 mm thick) which is suitable as a self-supporting test field material, i.e. which can be used without connection with a carrier layer over the whole area.
A test field material within the meaning of the present invention is any thin, flat structure which as a separate component can be integrated into the test field of a test carrier. The test field may consist exclusively of this test field material. There may also be used a plurality of test field materials according to the invention or combinations with other layer materials commonly employed in test carrier technology, for example paper, plastic membranes or fibre materials.
The aim of the invention is to provide a test field material which, with extreme layer thinness, has self-supporting properties and fulfils the additional stringent requirements in the field of body fluid analysis.
To achieve this aim, in a method of the kind described in the preamble it is proposed that a reagent film mass be pressed from an application side into a carrier material ribbon consisting of an open-pored fibre structure in such a way that it penetrates extensively into the pores of the carrier material, the impregnating mass on the opposite side is smoothed by the relative motion of the ribbon and a smoothing tool in such a way that the pores of the composite fibre structure are spanned by the reagent film mass and the ribbon of test field material thus produced is dried without contact.
The term "open pored fibre structure" signifies any type of textile structure of fibres or threads to create a thin, open-pored layer. Examples are woven or knitted fabric and mats. The use of a single-layer woven or knitted fabric, preferably consisting of monofilamentous threads, has proved especially successful. The mean pore width of the composite fibre structure should be between 0.02 mm and 0.08 mm, preferably between 0.03 mm and 0.05 mm.
The compo
REFERENCES:
patent: 4292272 (1981-09-01), Kitajuma et al.
patent: 4588614 (1986-05-01), Lauchenauer
patent: 4604264 (1986-08-01), Rothe et al.
Gotschel Hans
Mosoiu Dan
Plesch Winfried
Boehringer Mannheim GmbH
Johnston Jill A.
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