Method for the isolation and purification of taxol and its natur

Details Method for the isolation and purification of taxol and its natur Method for the isolation and purification of taxol and its natur

1995-05-05

1997-09-23

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560107, 514449, 514510, 210656, 210660, C07D30514, C07C 6976

Patent

active

056706731

ABSTRACT:
An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxol and the taxol analogues to be adsorbed on the adsorbent, and recovering taxol and the natural analogues of taxol from the adsorbent by elution with an elutant. The compounds thus isolated in pure form are taxol, taxol-7-xyloside, 10-deacetyltaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deacetylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, brevitaxane A, and taxiflorine.

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