Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1985-05-30
1987-03-10
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
424 89, 530380, 530415, 530806, 530826, 530808, A61K 3929, C07K 318, C07K 328
Patent
active
046491929
ABSTRACT:
The supernatant of engineered yeast cells having produced hepatitis B surface antigaen and disrupted in the presence of a polysorbate non-ionic detergent is clarified by addition of urea and adsorbed on colloidal silica from which the purified antigen is desorbed with a low ionic strength buffer supplemented with urea and a polysorbate non-ionic detergent.
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Simonet Guy
Van Wijnendaele Frans
Lentz Edward T.
Lourie Alan D.
Schain Howard E.
Smith Kline-RIT
Williams Janice E.
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