Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-04-29
2008-04-29
Saeed, Kamal A (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S405000
Reexamination Certificate
active
10574871
ABSTRACT:
A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.
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patent: 94/26751 (1994-11-01), None
Abiko et al. “An Improved, Convenient Procedure for Reduction of Amino Acids to Aminoalcohols: Use of NaBH4-H2SO4” Tetrahedron Letters vol. 33, No. 38 p. 5517-5518.
Bell et al. “The Reduction of Organic Halogen Compounds by Sodium Borohydride” The Journal of Organic Chemistry, vol. 34 No. 12 Dec. 1969 p. 3923-3926.
Periasmy “New Organic Synthetic Methods Using the NaBH4/I2System” ACS Symposium Series, 2001, 783 p. 65-78.
Bertrand Blandine
Burgos Alain
Frein Stéphane
Pluvie Jean-François
Roussiasse Sonia
Merchant & Gould P.C.
Saeed Kamal A
ZaCh System S.p.A.
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