Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-01-29
2008-01-29
Helms, Larry R. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S002000
Reexamination Certificate
active
10524544
ABSTRACT:
The invention relates to a method for enriching tumor cells from a body fluid, in which a cell separation medium of a specific density is overlaid with the body fluid and it is subsequently determined whether the enriched cells express an epithelial marker, for example a cytokeratin. A kit suitable for this method is likewise provided.
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Traweek, S.T., Liu, J., and Battifora, H. Keratin gene expression in non-epithelial tissues. 1993. American Journal of Pathology, vol. 142 No. 4, pp. 1111-1118.
Slade, M.J. and Coombes, R.C. The clinical significance of disseminated tumor cells in breast cancer. 2007. Nature Clinical Practice Oncology. vol. 4 No. 1; pp. 30-41.
Goetz, Alexander, “Mit OncoQuick den Metastasen auf der Spur”, BIOforum forschung und entwicklung, p. 394, 2001, vol. 24, XP-002261836, GIT VERLAG GmbH, Darmstadt, Germany.
English language translation of Abstract paragraph for Goetz article “Mit OncoQuick den Metastasen auf der Spur”, BIOforum forschung und entwicklung, 24 (201) 394, 2001.
Hexal Gentech Forschungs-GmbH: Oncoquick-TM Gebrauchsanleitung, Online!; greiner bio-one, oncoQuick Instruction Manual, http://www.hexal-gentech.de/products/man—d.pdf, XP002261835, Feb. 12, 2007.
Alexander W. Goetz et al., “Enrichment of disseminated breast cancer cells from human peripheral blood by advanced density gradient centrifugation”, Proceedings of the American Association for Cancer Research Annual Meeting, Mar. 2002, p. 733, vol. 43, XP002261837.
J. Bischoff et al., “Detection of disseminated tumor cells in bone marrow and peripheral blood of patients with metastatic breast cancer”, Annual Meeting of the American Society of Clinical Oncology, May 2002, XP002261838.
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Arent & Fox LLP
Gussow Anne M.
Helms Larry R.
Hexal Gentech ForschungsGmbH
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