Method for the immunochemical determination of hepatitis B core

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435810, 436518, 436820, G01N 5300, G01N 33543

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active

047014105

ABSTRACT:
The present invention concerns a method for detection of the core antigen of hepatitis B virus in a sample comprising a first incubation with carrier-bound antibodies directed against hepatitis B surface antigens and a second incubation with antibodies against the core antigen in the presence of a detergent.
Also claimed are test kits for carrying out this method and an immunochemical reagent comprising antibodies directed against the surface antigen and against the core antigen conjointly bound to a carrier.

REFERENCES:
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4157280 (1979-06-01), Halbert et al.
patent: 4241175 (1980-12-01), Miller et al.
patent: 4317810 (1982-03-01), Halbert et al.
patent: 4617260 (1986-10-01), McAleer et al.
Voller et al., Immunoassays for the 80s, pp. 367-369, University Park Press, Baltimore, 1983.
Chemical Abstracts, vol. 9, No. 1, 99:3880s, Jul. 4, 1983.
Biological Abstracts, vol. 69, No. 6, (U.S.), 38085, 1979.

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