Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1981-05-26
1984-07-03
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 23, 435184, 435810, 436528, G01N 3350, C12Q 138, C12N 999
Patent
active
044580134
ABSTRACT:
A method for the immunoassay of elastase-1 which comprises subjecting elastase-1 to be measured and a labelled antigen elastase-1, both having previously been treated with a synthetic elastase inhibitor, to a competitive reaction with anti-elastase-1 antibody, a kit of reagents for the immunoassay of elastase-1 which comprises a buffer liquid for immunoassay containing a synthetic elastase inhibitor, a labelled antigen elastase-1, a standard antigen elastase-1 and anti-elastase-1 antibody. The method and the kit of reagents for the immunoassay of elastase-1 are effectively utilized for diagnosis of pancreatic diseases, especially acute or chronic pancreatitis and cancer of the pancreas.
REFERENCES:
Carballo et al., "Radio Immunoassay of Plasma Elastase", Chem. Absts., vol. 81, No. 19, p. 196, (1974), Abs. No. 116407y.
Araki, et al., "Immunological Determination of Serum Elastase by Its Inhibition of Hemagglutinin," Chem. Absts., vol. 78, No. 25, p. 111, (1973), Abs. No. 155818g.
Ooyama, et al., FEBS Letters, vol. 77, No. 1, (1977), pp. 61-64.
Ooyama, et al., Igaku No Ayumi, vol. 101, No. 1, (1977), pp. 22-23.
Rifkin, et al., "A Sensitive Assay for Elastase Employing Radioactive Elastin Coupled to Sepharose", Anal. Biochem., vol. 79, (1977), pp. 268-275.
Bergmeyer et al., Methods of Enzymatic Analysis, vol. 2, Academic Press, N.Y., (1974), pp. 1041-1045.
Ooyama, et al., "Radioimmunoassay of Pig Pancreatic Elastase", Chem. Absts., vol. 87, No. 5, (1977), p. 140, Abs. No. 34825j, p. 141, Abs. No. 34833k.
Ooyama, et al., Igaku No Ayumi, vol. 105, No. 3, (1978), pp. 91-97.
Dainabot Kabushiki Kaisha
Kepplinger Esther M.
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