Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-07-15
2008-07-15
Mertz, Prema M (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S006120
Reexamination Certificate
active
10510413
ABSTRACT:
The present invention provides for a method for identifying an agent that has an inhibitory effect on the complex-formation of an ARE-containing mRNA and an HuR protein.
REFERENCES:
patent: 6180604 (2001-01-01), Fraser et al.
patent: 6436636 (2002-08-01), Port et al.
patent: 2002/0165186 (2002-11-01), Hauber et al.
patent: 0 873 998 (1998-10-01), None
patent: 93/23531 (1993-11-01), None
patent: 98/04923 (1998-02-01), None
patent: 98/39484 (1998-09-01), None
patent: 99/61605 (1999-12-01), None
patent: 00/39314 (2000-07-01), None
patent: 00/67023 (2000-11-01), None
patent: 01/12213 (2001-02-01), None
patent: 01/34624 (2001-05-01), None
patent: 01/48193 (2001-07-01), None
patent: 01/83691 (2001-11-01), None
Myer, et al. Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J. Apr. 15, 1997;16(8):2130-9.
Ausserlechner et al., “Chemiluminescence-Based RNase Protection Assays for Simulaneous Quantification of Procollagen mRNAs Containing AU-Rich Regions”, BioTechniques, vol. 24, pp. 366-370 (1998).
Chrzanowska-Lightowlers et al., “Fending off Decay: A Combinatorial Approach in Intact Cells for Identifyign mRNA Stability Elements”, RNA, vol. 7, pp. 435-444 (2001).
Fritz et al., “An in Vitro Assay to Study Regulated mRNA Stability”, Science's Stke, vol. 61, PL1, pp. 1-13 (2000).
Brennan et al., “Protein Ligands to HuR Modulate its Interaction with Target mRNAs In Vivo”, J. Cell Biol., vol. 151, No. 1, pp. 1-13 (2000).
Guhaniyogi et al., “Regulation of mRNA Stability in Mammalian Cells”, Gene, vol. 265, No. 1-2, pp. 11-23 (2001).
Ma et al., “Cloning and Characterization of Hur, a Ubiquitously Expressed Elav-like Protein”, J. Biol. Chem., vol. 271, No. 14, pp. 8144-8151 (1996).
Peng et al., “RNA Stabilization by the Au-rich Element Binding Protein, HuR, an ELAV Protein”, EMBO (Eur. Mol. Biol. Organ.) J., vol. 17, No. 12, pp. 3461-3470 (1998).
Auer Manfred
Meisner Nicole-Claudia
Uhl Volker
Mertz Prema M
Novartis AG
Prince John
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