Method for the identification of antagonists of a...

Details Method for the identification of antagonists of a... Method for the identification of antagonists of a...

2003-09-25

2008-08-19

Ulm, John D (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007210, C436S501000

Reexamination Certificate

active

07413867

ABSTRACT:
The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block bitter taste transduction, or enhance bitter taste response.

REFERENCES:
patent: 2002/0094551 (2002-07-01), Adler
patent: 2004/0248123 (2004-12-01), Drayna et al.
patent: WO 01/77676 (2001-10-01), None
Bufe, B. et al., “The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides,” Nature Genetics (Nov. 2002), p. 397-401, vol. 32.
Bufe, B. et al., “Homo sapienscandidate receptor TAS2R38 gene,” Database EMBL (Online) (Apr. 29, 2002), Database accession No. AF494231.
Chandrashekar, J. et al., “T2Rs Function as Bitter Taste Receptors,” Cell (Mar. 17, 2000), p. 703-711, vol. 100.
Margolskee, R.F., “Molecular Mechanisms of Bitter and Sweet Taste Transduction,” J. Biol. Chem. (Jan. 4, 2002), p. 1-4, vol. 277, No. 1.

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