Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1997-02-11
2000-01-11
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 42419711, 4241921, 4241931, 4242001, 4242491, 435 691, 435 697, 530350, A61K 39095
Patent
active
060132671
ABSTRACT:
The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins and fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
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Blake Milan S.
Hronowski Lucjan J.J.
Liang Shu-Mei
Pullen Jeffrey K.
Qi Huilin L.
Graser Jennifer
Housel James C.
North American Vaccine, Inc.
The Rockefeller University
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