Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-07-23
1995-08-08
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 693, 435 697, 4351723, 43525233, 4353201, 435844, 530417, 935 10, 935 12, 935 29, 935 73, C12N 1531, C12N 1562, C12N 1567, C12N 1570
Patent
active
054398088
ABSTRACT:
The present invention relates, in general, to a method for the high level expression of the outer membrane protein meningococcal group B porin proteins and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein meningococcal group B porin proteins in E. coli wherein the meningococcal group B porin proteins yard fusion proteins thereof comprise more than 2% of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of the meningococcal group B porin proteins and fusion proteins thereof and to their use in vaccines.
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Blake Milan S.
Hronowski Lucjan J. J.
Liang Shu-Mei
Pullen Jeffrey K.
Qi Huilin L.
Moore William W.
North American Vaccine, Inc.
The Rockefeller University
Wax Robert A.
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