Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...
Reexamination Certificate
2007-10-23
2007-10-23
Fortuna, Ana (Department: 1723)
Liquid purification or separation
Processes
Liquid/liquid solvent or colloidal extraction or diffusing...
C210S645000, C436S811000, C436S820000, C436S825000, C435S173100, C435S069100, C324S347000
Reexamination Certificate
active
10476440
ABSTRACT:
The invention relates to a method for the extra-corporeal qualitative and/or quantitative recording of neuro-toxic substances in the blood plasma of an individual. According to said method, a system containing neurones or neuronal networks, which have been cultivated on or applied to a micro-electrode array or a neuro-chip, in addition to a device for measuring the electrical activity of at least one or several of said neurones are provided, the neurones are brought into contact with a prepared sample of plasma and the electrical activity of the neurones is measured. The aim of the invention is to develop and improve said method in such a way that it supplies reliable, reproducible results for the recording of neuro-toxic substances in the blood plasma of an individual, in particular in the case of encephalopathic conditions, such as for example hepatic failure, or of coma conditions of various origins. To achieve this, prior to measurement, the blood plasma of an individual is prepared by being subjected to a filtration method, preferably an ultra-filtration method, whereby an exclusion limit, which causes the most extensive separation possible of the plasma protein from the other dissolved substances is selected, and/or prior to measurement, the blood plasma of an individual is prepared by being subjected to an extraction of liposoluble substances, using a solvent for liposoluble substances, and the ultra-filtrate or the extract containing the liposoluble substances, or both are used in succession or are blended together for the measurement.
REFERENCES:
patent: 5480554 (1996-01-01), Degen et al.
patent: 6911474 (2005-06-01), Piomelli et al.
patent: 7033500 (2006-04-01), Bomberger et al.
patent: 7064147 (2006-06-01), Barta et al.
patent: 4315718 (1993-11-01), None
patent: 19544297 (1997-06-01), None
patent: 19932720 (2001-01-01), None
patent: 0760103 (1997-03-01), None
Reaction of the Neuronal Networks in Vitro to Ulrafiltrates of Liver Coma Plasma Influence of Mars Treatments, J. Loock, J. Stange, S. Mitzner, R. Schmidt, D. Schiffman, D. Weiss, E.W. Keefer, G.W. Gross; Artif Organs, vol. 23, No. 7, 1999.
Reaction of the Neuronal Networks in Vitro to Ultrafiltrates of Liver Coma Plasma Influence of Mars Treatments, J. Loock, J. Stange, S. Mitzner, R. Schmidt, D. Schiffman, D. Weiss, E.W. Keefer, G.W. Gross; The International Journal of Artificial Organs, vol. 22, No. 6, 1999.
Gramowski Alexandra
Gross Gunter W.
Loock Jan
Mitzner Steffen R.
Schiffmann Dietmar
Dunn Michael L.
Fortuna Ana
LandOfFree
Method for the extra-corporeal qualitative and/or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the extra-corporeal qualitative and/or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the extra-corporeal qualitative and/or... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3847659