Method for the ESR-spectroscopic detection of changes in the...

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

Reexamination Certificate

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C435S007100, C435S810000, C435S975000, C436S808000

Reexamination Certificate

active

10220170

ABSTRACT:
The invention relates to method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample. Said method can be used in the medical, biological, biotechnological and veterinary praxis for diagnostic purposes and/or for monitoring physiological or pathological changes in the human or animal body or for the quality control of albumin-containing preparations, especially blood products. The invention further relates to an ESR spectrometer for carrying out the inventive method, which—being an automated ESR analyzer—allows for a simple and reliable handling required in modern clinical laboratories. The inventive ESR spectrometer integrates automatic device controls, signal registration and signal evaluation in combination with a computer program for the diagnostic analysis of the measured data.

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Tsvetan G. Gantchev, “Binding Interactions and Conformational Changes Induced by Sulfonated Aluminum Phthalocyanines in Human Serum Albumin,” Archives of Biochemistry and Biophysics, vol. 366, No. 1, Jun. 1, 1999, pp. 21-30.

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