Chemistry: analytical and immunological testing – Including sample preparation
Reexamination Certificate
2001-08-09
2008-11-11
Navarro, Mark (Department: 1645)
Chemistry: analytical and immunological testing
Including sample preparation
C435S007200, C435S007230, C435S007320, C435S007330, C435S007340, C435S007350, C435S007950, C435S340000, C435S344000, C435S372100, C436S017000, C436S064000, C436S177000
Reexamination Certificate
active
07449340
ABSTRACT:
The present invention relates to a method for the early diagnosis of cancer in a subject, which is based on determination of the relative fraction of microorganisms derived from the feces of the subject, as compared to the total count of microorganisms in the same of corresponding sample. This relation has been found to be indicative of the presence or absence of cancer in said subject.After isolating at least one of the microorganisms from the fecal sample to form a so-called diagnostic sample, and incubating, for a sufficient time, the diagnostic sample with cancer cells. The microorganism being in an amount corresponding to its relative fraction in the original fecal sample, the cancerolytic activity of the microorganism/s is indicative to the presence or absence of cancer cells in the subject. The cancerolytic activity is expressed by terms of a tumor cell necrosis index (TCNI).Further, the method of the invention is based on determining level of expression or level of activity of L-PAR II in a fecal-derived microorganism/s sample, the level determined being also indicative of the presence or absence of cancer cells in the subject from which the fecal sample was derived.
REFERENCES:
patent: 3476514 (1969-11-01), Roth
patent: 5344762 (1994-09-01), Karapetian
patent: 5455160 (1995-10-01), Fagerhol et al.
patent: 5952200 (1999-09-01), Johnson et al.
patent: 0685739 (2001-08-01), None
patent: 1587244 (1981-04-01), None
English Abstract of JP56166124A2 dated Dec. 21, 1981.
English Abstract of JP6258324 Dated Sep. 16, 1994.
Report of a WHO Expert Committee “Early Detection of Cancer”World Health Organization Technical Report Series, No. 422, (1969).
Oleinik, S.F., et al. “Carcinolytic and Carcinogenic Intestinal Coliflora”Vrachebnoye-delo, vol. 5, p. 13-17, (1968).
Karapetian Anahit
Levitt Mark L.
Tenne Gil
Era-Massis, Inc.
Hines J.
Navarro Mark
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