Method for the disruption of lipid-containing viruses

Details Method for the disruption of lipid-containing viruses Method for the disruption of lipid-containing viruses

1974-09-19

1976-06-08

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3918, A61K 3929

Patent

active

039624218

ABSTRACT:
Virus-containing media are treated and the viruses broken down into sub-units by mixing with trialkyl phosphates in the presence of a wetting agent. In comparison with conventional means, sub-unit vaccines prepared therefrom have low toxic pyrogen content, and influenza viruses of Types A and B are disrupted without substantial decreases in neuraminidase level. The method can be used on viruses contained in relatively dilute allantoic fluids as well as those in concentrated centrifugates.

REFERENCES:
webster et al. - J. Immunology (vol. 96), pp. 596-605 (1966).

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