Method for the disinsertion of vitreous body by an enzyme which

Details Method for the disinsertion of vitreous body by an enzyme which Method for the disinsertion of vitreous body by an enzyme which

1992-06-05

1994-03-08

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9462, A61K 3754

Patent

active

052925099

ABSTRACT:
A method for selectively and completely disinserting the ocular vitreous body, epiretinal membranes and/or fibrocellular membranes from the neural retina, ciliary epithelium and posterior lens surface of the mammalian eye as an adjunct to vitrectomy comprises administering to the eye an effective amount of a protease-free glycosaminoglycanase enzyme, such as chondroitinase ABC, adapted to disrupt and/or degrade chondroitin sulfate glycosaminoglycan/proteoglycan localized specifically to sites of vitreoretinal adhesion and thereby permit complete disinsertion of the vitreous body and/or epiretinal membranes.

REFERENCES:
patent: 4174389 (1979-11-01), Cope
patent: 4524065 (1985-06-01), Pinnell
patent: 4696816 (1987-09-01), Brown
Winkler et al. "Hyaluronidase and Retinal Function", Arch Ophthalmol, 103 (11), pp. 1743-1746, 1985.
Thomson, "Addition of hyaluronidase to lignocaine with adrenaline for retrobulbar anesthesia in the surgery of senile cataract", Am. J. Ophthalmol, 107, p. 99 (1989), Abstract.

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