Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-08-27
1999-06-29
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 723, 436 64, 436813, G01N 33574, G01N 3348, C12Q 168
Patent
active
059167513
ABSTRACT:
A method for the early diagnosing of selected adenocarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene, the gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referred to as the endometrial bleeding associated factor (ebaf) gene. The bodily sample can be tissue from a specific organ in the body, or a blood sample. Increased levels of ebaf in the sample relative to basal levels may be indicative of a mucinous adenocarcinoma of the colon or ovaries, or an adenocarcinoma of the testis.
REFERENCES:
RNA Image Kit Product Brochure, 1993, pp. 1-21.
"DNA Sequencing by the Dideoxy Method," Sequences Ver. 2.0 A New Genetically Engineered Enzyme for DNA Sequencing, U.S. Biochemical Corp., 1988-89, pp. 7-29-7-35.
Pegn Liang, Weimin Zhu, Xiaoying Zhang, Zhen Guo, Robert P. O'Connell, Lidia Averboukh, Feilan Wang and Arthur B. Pardee, "Differential Display Using One-Base Anchored Oliogo-dT Primers," Nucleic Acids Research, 1994, vol. 22, No. 25, pp. 5763-5764.
Analysis of RNA by Northern and Slot Blot Hybridization, Current Protocols in Molecular Biology, Unit 4.9, 1993, pp. 4.9.1-4.9.14.
Ravi Kothapalli, Ibrahim Buyuksal, Shi-Qu Wu, Nasser Chegini and Siamak Tabibzadeh, "Detection of ebaf, a Novel Human Gene of the Transforming Growth Factor B Superfamily," Rapid Publication, The American Society for Clinical Investigation, Inc., vol. 99, No. 10, May 1997, pp. 2342-2350.
Siamak Tabibzadeh, Ravi Kothapalli, Ibrahim Buyuksal, "Distinct Tumor Specific Expression of TGFB4 (ebaf), a Novel Human Gene of the TGF-B Superfamily," Frontiers in Bioscience 2, Jul. 1997, pp. 18-25.
Amersham Life Science Brochure, 1994, pp. 1-29.
Kothapalli Ravi
Tabibzadeh Siamak
Bansal Geetha P.
Scheiner Toni R.
University of South Florida
LandOfFree
Method for the diagnosis of selected adenocarcinomas does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the diagnosis of selected adenocarcinomas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the diagnosis of selected adenocarcinomas will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1374881