Method for the determination of the plasminogen activator activi

Details Method for the determination of the plasminogen activator activi Method for the determination of the plasminogen activator activi

1993-07-26

1997-03-04

Paden, Carolyn

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 18, 435174, 435 23, 435 24, 530300, C12Q 156

Patent

active

056078374

ABSTRACT:
The disclosed invention provides a method for determining the plasminogen activator (PA) activity in a biological fluid. The method involves the use of proteolytically-degraded plasminogen and effectively eliminates the influence of alpha-2-antiplasmin on the determination of PA activity.

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Moroz, Leonard A.; Mini-Plasminogen: A Mechanism for Leukocyte Modulation of Plasminogen Activation by Urokinase; Jul. 1981; Blood, vol. 58, No. 1, pp. 97-104.
Holvoet, Paul et al.; A Monoclonal Antibody Specific for Lys-plasminogen; Oct. 5, 1985; The Journal of Biological Chemistry, vol. 260, No. 22, pp. 12106-12111.
Chmielewska, J. et al.; Determination of Tissue Plasminogen Activator and Its "Fast" Inhibitor in Plasma; 1986; Clinical Chemistry, vol. 32, No. 3, pp. 482-485.
Berne et al, eds. Physiology. St. Louis., C. V. Mosby, 1988 pp. 382-385.

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